Uranium bioaccumulation and biological disorders induced in zebrafish (Danio rerio) after a depleted uranium waterborne exposure

Authors:Barillet, SabrinaAdam-Guillermin, ChristellePalluel, OlivierPorcher, Jean-MarcDevaux, Alain

Source:ENVIRONMENTAL POLLUTION

Volume:159

DOI:10.1016/j.envpol.2010.10.013

Published:2011

Document Type:Article

Abstract:Because of its toxicity and its ubiquity within aquatic compartments, uranium (U) represents a significant hazard to aquatic species such as fish. In a previous study, we investigated some biological responses in zebrafish either exposed to depleted or to enriched U (i.e., to different radiological activities). However, results required further experiments to better understand biological responses. Moreover, we failed to clearly demonstrate a significant relationship between biological effects and U radiological activity. We therefore chose to herein examine U bioaccumulation and induced effects in zebrafish according to a chemical dose-response approach. Results showed that U is highly bioconcentrated in fish, according to a time- and concentration-dependent model. Additionally, hepatic antioxidant defenses, red blood cells DNA integrity and brain acetylcholinesterase activity were found to be significantly altered. Generally, the higher the U concentration, the sooner and/or the greater the effect, suggesting a close relationship between accumulation and effect. (C) 2010 Elsevier Ltd. All rights reserved.

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Reprint Address:Barillet, S (corresponding author), DEI SECRE LRE, IRSN Inst Radiol Protect & Nucl Safety, Lab Radioecol & Ecotoxicol, Bat 186,BP 3, F-13115 St Paul Les Durance, France.

Addresses:[Barillet, Sabrina; Adam-Guillermin, Christelle] DEI SECRE LRE, IRSN Inst Radiol Protect & Nucl Safety, Lab Radioecol & Ecotoxicol, F-13115 St Paul Les Durance, France. [Palluel, Olivier; Porcher, Jean-Marc] INERIS Natl Inst Ind Environm & Risks, Ecotoxicol Risk Assessment Unit, Parc Technol ALATA, F-60550 Verneuil En Halatte, France. [Devaux, Alain] Univ Lyon, INRA, EFPA SA, Environm Sci Lab LSE,ENTPE, F-69518 Vaulx En Velin, France.

E-mail Addresses:sabrina.barillet@free.fr; christelle.adam-guillermin@irsn.fr; olivier.palluel@ineris.fr; jean-marc.porcher@ineris.fr; alain.devaux@entpe.fr

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