A plea for the integration of Green Toxicology in sustainable bioeconomy strategies - Biosurfactants and microgel-based pesticide release systems as examples
Authors:Johann, Sarah Weichert, Fabian G. Schroeer, Lukas Stratemann, Lucas Kaempfer, Christoph Seiler, Thomas-Benjamin Heger, Sebastian Toepel, Alexander Sassmann, Tim Pich, Andrij Jakob, Felix Schwaneberg, Ulrich Stoffels, Peter Philipp, Magnus Terfruechte, Marius Loeschcke, Anita Schipper, Kerstin Feldbruegge, Michael Ihling, Nina Buechs, Jochen Bator, Isabel Tiso, Till Blank, Lars M. Ross-Nickoll, Martina Hollert, Henner
Volume:426
DOI:10.1016/j.jhazmat.2021.127800
Published:2022
Document Type:Article
Abstract:A key aspect of the transformation of the economic sector towards a sustainable bioeconomy is the development of environmentally friendly alternatives for hitherto used chemicals, which have negative impacts on environmental health. However, the implementation of an ecotoxicological hazard assessment at early steps of product development to elaborate the most promising candidates of lowest harm is scarce in industry practice. The present article introduces the interdisciplinary proof-of-concept project GreenToxiConomy, which shows the successful application of a Green Toxicology strategy for biosurfactants and a novel microgel-based pesticide release system. Both groups are promising candidates for industrial and agricultural applications and the ecotoxicological characterization is yet missing important information. An iterative substance- and applicationoriented bioassay battery for acute and mechanism-specific toxicity within aquatic and terrestrial model species is introduced for both potentially hazardous materials getting into contact with humans and ending up in the environment. By applying in silico QSAR-based models on genotoxicity, endocrine disruption, skin sensitization and acute toxicity to algae, daphnids and fish, individual biosurfactants resulted in deviating toxicity, suggesting a pre-ranking of the compounds. Experimental toxicity assessment will further complement the predicted toxicity to elaborate the most promising candidates in an efficient pre-screening of new substances.
Author Information
Corresponding Author:Johann, S; Hollert, H (通讯作者)，Goethe Univ Frankfurt, Dept Evolutionary Ecol & Environm Toxicol, Max von Laue Str 13, D-60438 Frankfurt, Germany.
Reprint Address:Johann, S; Hollert, H (通讯作者)，Goethe Univ Frankfurt, Dept Evolutionary Ecol & Environm Toxicol, Max von Laue Str 13, D-60438 Frankfurt, Germany.
Addresses:[Johann, Sarah; Weichert, Fabian G.; Hollert, Henner] Goethe Univ Frankfurt, Dept Evolutionary Ecol & Environm Toxicol, Max von Laue Str 13, D-60438 Frankfurt, Germany; [Weichert, Fabian G.; Schroeer, Lukas; Stratemann, Lucas; Kaempfer, Christoph; Seiler, Thomas-Benjamin; Heger, Sebastian; Ross-Nickoll, Martina] Rhein Westfal TH Aachen, Inst Environm Res, Dept Ecosyst Anal, Worringerweg 1, D-52074 Aachen, Germany; [Seiler, Thomas-Benjamin] Hyg Inst Ruhrgebiet, Rotthauser Str 21, D-45879 Gelsenkirchen, Germany; [Toepel, Alexander; Sassmann, Tim; Pich, Andrij; Jakob, Felix; Schwaneberg, Ulrich; Stoffels, Peter; Philipp, Magnus; Terfruechte, Marius; Loeschcke, Anita; Schipper, Kerstin; Feldbruegge, Michael; Ihling, Nina; Buechs, Jochen; Bator, Isabel; Tiso, Till; Blank, Lars M.; Ross-Nickoll, Martina; Hollert, Henner] Forschungszentrum Julich, Bioecon Sci Ctr BioSC, Wilhelm Johnen Str, D-52425 Julich, Germany; [Toepel, Alexander; Sassmann, Tim; Pich, Andrij] Rhein Westfal TH Aachen, Inst Tech & Macromol Chem, Worringerweg 1, D-52074 Aachen, Germany; [Toepel, Alexander; Sassmann, Tim; Pich, Andrij; Jakob, Felix; Schwaneberg, Ulrich] DWI Leibniz Inst Interact Mat, Forckenbeckstr 50, D-52074 Aachen, Germany; [Pich, Andrij] Maastricht Univ, Aachen Maastricht Inst Biobased Mat, Urmonderbaan 22, NL-6167 RD Geleen, Netherlands; [Schwaneberg, Ulrich] Rhein Westfal TH Aachen, Inst Biotechnol, Worringerweg 3, D-52074 Aachen, Germany; [Stoffels, Peter; Philipp, Magnus; Terfruechte, Marius; Schipper, Kerstin; Feldbruegge, Michael] Heinrich Heine Univ Dusseldorf, Inst Microbiol, Dept Biol, Univ Str 1, D-40225 Dusseldorf, Germany; [Ihling, Nina; Buechs, Jochen] Rhein Westfal TH Aachen, Aachener Verfahrenstech Biochem Engn, Forckenbeckstr 51, D-52074 Aachen, Germany; [Bator, Isabel; Tiso, Till; Blank, Lars M.] Rhein Westfal TH Aachen, Inst Appl Microbiol, Worringerweg 1, D-52074 Aachen, Germany; [Loeschcke, Anita] Heinrich Heine Univ Dusseldorf, Inst Mol Enzyme Technol, Forschungszentrum Julich, D-52425 Julich, Germany
E-mail Addresses:johann@bio.uni-frankfurt.de; hollert@bio.uni-frankfurt.de